                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> FGF21 COMPOSITIONS FOR TREATMENT OR PREVENTION OF 
      NEOVASCULARIZATION OF THE EYE AND METHODS THEREFOR

<130> 048218-551001WO

<140> PCT/US2018/016476
<141> 2018-02-01

<150> 62/595,917
<151> 2017-12-07

<150> 62/453,352
<151> 2017-02-01

<160> 49    

<170> PatentIn version 3.5

<210> 1
<211> 180
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg 
1               5                   10                  15      


Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu 
            20                  25                  30          


Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro 
        35                  40                  45              


Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile 
    50                  55                  60                  


Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala 
65                  70                  75                  80  


Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu 
                85                  90                  95      


Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly 
            100                 105                 110         


Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Cys 
        115                 120                 125             


Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
    130                 135                 140                 


Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro 
                165                 170                 175     


Ser Tyr Ala Ser 
            180 


<210> 2
<211> 5324
<212> DNA
<213> Homo sapiens

<400> 2
cacagcacag caggatgact gcgggcaggc ctagataata cccagcctcc cacaagaagc       60

tggtggagca gagtgttccc tgactcctcc aagaaaagga gattcccttt cgtggtctgc      120

tgagtaacgg gtgccttccc agacactggc gttcccgctt gaccaaggag ccctcaagag      180

gcccttatgc cggtgtgaca gaaggctcac ctcttgcctt ctaggtcact tctcacaatg      240

tcccttcagt acctgaccct atacccaccg gttgtttcct ggttatatta gttatacaac      300

aaagaataaa agtaatagct aatgattaat aatgtttaca ctaatgattg atactgtcca      360

tgatcatctc tatatctaat ttgtatgata actattctta ttctaactat tttctttatt      420

atactgaaac agtttgtgcc ttcagtctct tgcctcggca cctgggtaat ccttccccac      480

agactgaccc tcccattcaa gatacatcaa tgtcaaagac tcaggagttt gacttgattc      540

ccagaagttt aaccatcatc tccccaggct cgggactccc agcacccaga cccttctgct      600

cacacccagc agtccaggcc cccagaccct cctccctcag acttaggagt ccaggctccc      660

ggcccctcct tcctcagacc caggagtcca agccccctgc ccctccttcc tcagacccag      720

gagtccagga ccccagcccc tccttcctca cacccacgag tccagatccc tagcccctac      780

tccctcagac ccaggagtcc agaccaaagc tccctcctcc ctcagaccca ggagcccaag      840

ttccccagcc cctcctccct cagatccagg agtacaggcc cagcccctcc tccctcagac      900

ccctcctccc tcagatccag gagtacaggc ccagaccctc ctccctcaga cccaggagtc      960

caggcccccc acccctcctc cctcagaccc aggagtccag agccccagcc ctcctccctc     1020

agacacagaa ggcctaccct tgcaccctta ggggctccag gaaattagcc aacctgtctt     1080

ccctctgggt gcccactcca gggcctggct tggctgccaa ctccagtcag ggactttcag     1140

ccacccctcc ccccaggtta tttcaggagc acctgcctgg gcctgggatg gcttctctgg     1200

tgaaagaaac accaggattg catcagggag gaggaggctg ggatgtccag ggtctgagca     1260

tctgagcagg gacagatgag gttgaggttg gcccacggcc aggtgagagg cttccaaggc     1320

aggatacttg tgtctcagat gcggtcgctt ctttcataca gcaattgccg ccttgctgag     1380

gatcaaggaa cctcagtgtc agatcacgcc ctccccccaa acttagaaat tcagatgggg     1440

cgcagaaatt tctcttgttc tgcgtgatct gcatagatgg tccaagaggt ggtttttcca     1500

ggagcccagc acccctcctc cctccgactc aggtgcttga gaccccagat ccttctctct     1560

gagactcagg aatgtgggcc cccagcccct ttcacctggg tcccagctaa cccgatcctc     1620

ccctccctca tcccctagac ccaggagtct ggccctccat tgaaaggacc ccaggttaca     1680

tcatccattc aggctgccct tgccacgatg gaattctgta gctcctgcca aatgggtcaa     1740

atatcatggt tcaggcgcag ggagggtgat tgggcgggcc tgtctgggta taaattctgg     1800

agcttctgca tctatcccaa aaaacaaggg tgttctgtca gctgaggatc cagccgaaag     1860

aggagccagg cactcaggcc acctgagtct actcacctgg acaactggaa tctggcacca     1920

attctaaacc actcagcttc tccgagctca caccccggag atcacctgag gacccgagcc     1980

attgatggac tcggacgaga ccgggttcga gcactcaggg ctgtgggttt ctgtgctggc     2040

tggtcttctg ctgggagcct gccaggcaca ccccatccct gactccagtc ctctcctgca     2100

attcgggggc caagtccggc agcggtacct ctacacagat gatgcccagc agacagaagc     2160

ccacctggag atcagggagg atgggacggt ggggggcgct gctgaccaga gccccgaaag     2220

tgagtgtggg ccagagcctg ggtctgaggg aggaggggct gtgggtctgg attcctgggt     2280

ctgagggagg aggggctggg ggccttggcc cctgggtctg agggaggagg ggctggggat     2340

ctggactcct gggtctgagg gaggaggggc tggggatctg ggcccctggg tctgagggag     2400

gaggggctgg gtctggaccc ctgggtctga gggaggaggg gctgggggtc tggactcttg     2460

ggtttgaaga aggaagggct ggggtcctgg actcttgggt ctgagttggg agggggcttt     2520

ggcttgggct tctcctgggt ctgagggagg aggtaggctg tgggcttgga ctcccagggc     2580

tgggacagag ccggatggtg ggacagagtc gggtggtggg acagtcccgg gtgggagagg     2640

tcctcgaacc accttatcgc tttcacccct taggtctcct gcagctgaaa gccttgaagc     2700

cgggagttat tcaaatcttg ggagtcaaga catccaggtt cctgtgccag cggccagatg     2760

gggccctgta tggatcggtg agtttccagg accctcctca ccacccacca tgctcctcct     2820

atatgtcgcc ctcacagcct ggggtgcctt gtcttgctca tcccccccgg agccagactt     2880

gattctattt gctctgcacg cccccagctg caacatttgg aggttgaagt tgtcatcagt     2940

gtttgcaaga tgaggaaact gaggcccagg ccggggcgcc agtgacctca atcatgtgat     3000

gtgtggatgc tggagcggcc tgaggctcag gttattggga gtctcgtgat tcagtaaccc     3060

ctgctcctgc ccacacggcc cctgtgtgca cggctcatgc tgggcacagg gacactcggg     3120

gaagccatgg ccagtaaagt gaccaggacc ttgagtgcta gggagacacc ccgcctggcc     3180

tgagagagca ctgatggctc cgagggctgg aatgttctct gtgaagtctg aactgggagg     3240

caggtccctg caggagagcc ctggggtaaa aaacaaaacc tgccttgctg ttttgtttcc     3300

tagaggaggg gctgggggcc tggactcctg ggtctgaggg aggaggggct gggggcctgg     3360

acccctgggt ctgagggagg aggggctggg ggcctggaac cccgggtctg agggaggaga     3420

ggctggggcc tggaaccccg ggtctgaggg aggagaggct ggggcctgga accccgggtc     3480

tgagggagga ggcgctgggg gcctggactc ctgggtcgga tggaggagaa actagggtct     3540

ggacccctgg gtctgaggga ggaggcgctg ggggcctgga cccctgggtc tgagggaggc     3600

agggctgggg cctggatcct gggtcttaca tcaggaaaac agaggaaccc tgtctctgat     3660

cctgtttttg tcccctagct ccactttgac cctgaggcct gcagcttccg ggagctgctt     3720

cttgaggacg gatacaatgt ttaccagtcc gaagcccacg gcctcccgct gcacctgcca     3780

gggaacaagt ccccacaccg ggaccctgca ccccgaggac cagctcgctt cctgccacta     3840

ccaggcctgc cccccgcacc cccggagcca cccggaatcc tggcccccca gccccccgat     3900

gtgggctcct cggaccctct gagcatggtg ggaccttccc agggccgaag ccccagctac     3960

gcttcctgaa gccagaggct gtttactatg acatctcctc tttatttatt aggttattta     4020

tcttatttat ttttttattt ttcttacttg agataataaa gagttccaga ggaggataag     4080

aatgagcatg tgtgagtgtc tgagggaaga catggcagct gttttgtctc ccttggcccg     4140

gacaatcccc tctacacctc ccctcacgtg gtccgagggt cctggcttcc cactgggcct     4200

cacttttttc ttttcttttc tttttttttt tttgagacgg agtctcgctc tgtcacccag     4260

gctggagtgc agtggcgcga tcttggctca ctccaacctc cgcctcccag gttcaagcaa     4320

ttctcctgcc tcagccaccc gagtagctgt gattacaggc gtgcgccacc acacccagct     4380

aattttgtaa ttttagtaga gacagggttt cgccatgttg gccaggatgc tctccatctc     4440

ttgacttcat gacctgcctg ccttggcctc ccaaagtgct gggattacag gcttgagtca     4500

ctgtgcccag cccagcctca cttttctact ctgctaaagt gtccccaggg actgtggact     4560

atccctgctc tctgaaagga caagactggc cgggagtggt ggcttacgcc tgtaatccca     4620

gcactttggg aggccgaggc aggtggatca cgaggtcagg agattgagac tatcctggct     4680

aatacgatga aaccccgtct ctactaaaaa tacaaaaaca aaattagctg ggcgtggtgg     4740

cgggcgcctg tagtcccagc tactccggag gctgaggcag aatggcgtga atgcgggagg     4800

cggagcttgc agtgagccga gatcgcgcca ctgcactcca gcccaggcca cagagcgaga     4860

ttccatctca aaaaaataaa taaataaata aataaataaa taaatataaa aataaaatga     4920

aagagcagga cttctttcta caacccctca acttgtgtga gcgttgtgta actatttcat     4980

agagctacct caataacagg ggagctttta cgaggtgaca cagcacactc acatcctcat     5040

gggagatgta gttttctggc atcatttagc agcaggaatg agatctgttg ggcctcaaat     5100

ctgggacaag gactcctggg tcctggagta ggtttggggc tagtgtaaca cccaagttct     5160

ggggaatcag tgggctggac atctggacac ctggatcaca ggagaactgg ggactgcaga     5220

cttaggcatc ctggtctgag aaaaaagggg ctggagggtg ggagtttggg ttctcaggaa     5280

aaggagctga aacctggaat tcttccatct gggtccttat gaac                      5324


<210> 3
<211> 1332
<212> DNA
<213> Homo sapiens

<400> 3
gaggcttcca aggcaggata cttgtgtctc agatgcggtc gcttctttca tacagcaatt       60

gccgccttgc tgaggatcaa ggaacctcag tgtcagatca cgccctcccc ccaaacttag      120

aaattcagat ggggcgcaga aatttctctt gttctgcgtg atctgcatag atggtccaag      180

aggtggtttt tccaggagcc cagcacccct cctccctccg actcagaccc aggagtctgg      240

ccctccattg aaaggacccc aggttacatc atccattcag gctgcccttg ccacgatgga      300

attctgtagc tcctgccaaa tgggtcaaat atcatggttc aggcgcaggg agggtgattg      360

ggcgggcctg tctgggtata aattctggag cttctgcatc tatcccaaaa aacaagggtg      420

ttctgtcagc tgaggatcca gccgaaagag gagccaggca ctcaggccac ctgagtctac      480

tcacctggac aactggaatc tggcaccaat tctaaaccac tcagcttctc cgagctcaca      540

ccccggagat cacctgagga cccgagccat tgatggactc ggacgagacc gggttcgagc      600

actcaggact gtgggtttct gtgctggctg gtcttctgct gggagcctgc caggcacacc      660

ccatccctga ctccagtcct ctcctgcaat tcgggggcca agtccggcag cggtacctct      720

acacagatga tgcccagcag acagaagccc acctggagat cagggaggat gggacggtgg      780

ggggcgctgc tgaccagagc cccgaaagtc tcctgcagct gaaagccttg aagccgggag      840

ttattcaaat cttgggagtc aagacatcca ggttcctgtg ccagcggcca gatggggccc      900

tgtatggatc gctccacttt gaccctgagg cctgcagctt ccgggagctg cttcttgagg      960

acggatacaa tgtttaccag tccgaagccc acggcctccc gctgcacctg ccagggaaca     1020

agtccccaca ccgggaccct gcaccccgag gaccagctcg cttcctgcca ctaccaggcc     1080

tgccccccgc actcccggag ccacccggaa tcctggcccc ccagcccccc gatgtgggct     1140

cctcggaccc tctgagcatg gtgggacctt cccagggccg aagccccact acgcttcctg     1200

aagccagagg ctgtttacta tgacatctcc tctttattta ttaggttatt tatcttattt     1260

atttttttat ttttcttact tgagataata aagagttcca gaggaggata aaaaaaaaaa     1320

aaaaaaaaaa aa                                                         1332


<210> 4
<211> 947
<212> DNA
<213> Mus musculus

<400> 4
agacagcctt agtgtcttct cagctgggga ttcaacacag gagaaacagc cattcacttt       60

gcctgagccc cagtctgaac ctgacccatc cctgctgggc accggagtca gaacacaatt      120

ccagctgcct tggctcctca gccgctcgct tgccaggggc tctcccgaac ggagcgcagc      180

cctgatggaa tggatgagat ctagagttgg gaccctggga ctgtgggtcc gactgctgct      240

ggctgtcttc ctgctggggg tctaccaagc ataccccatc cctgactcca gccccctcct      300

ccagtttggg ggtcaagtcc ggcagaggta cctctacaca gatgacgacc aagacactga      360

agcccacctg gagatcaggg aggatggaac agtggtaggc gcagcacacc gcagtccaga      420

aagtctcctg gagctcaaag ccttgaagcc aggggtcatt caaatcctgg gtgtcaaagc      480

ctctaggttt ctttgccaac agccagatgg agctctctat ggatcgcctc actttgatcc      540

tgaggcctgc agcttcagag aactgctgct ggaggacggt tacaatgtgt accagtctga      600

agcccatggc ctgcccctgc gtctgcctca gaaggactcc ccaaaccagg atgcaacatc      660

ctggggacct gtgcgcttcc tgcccatgcc aggcctgctc cacgagcccc aagaccaagc      720

aggattcctg cccccagagc ccccagatgt gggctcctct gaccccctga gcatggtaga      780

gcctttacag ggccgaagcc ccagctatgc gtcctgactc ttcctgaatc tagggctgtt      840

tctttttggg tttccactta tttattacgg gtatttatct tatttattta ttttagtttt      900

tttttcttac ttggaataat aaagagtctg aaagaaaaat gtgtgtt                    947


<210> 5
<211> 210
<212> PRT
<213> Mus musculus

<400> 5
Met Glu Trp Met Arg Ser Arg Val Gly Thr Leu Gly Leu Trp Val Arg 
1               5                   10                  15      


Leu Leu Leu Ala Val Phe Leu Leu Gly Val Tyr Gln Ala Tyr Pro Ile 
            20                  25                  30          


Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
        35                  40                  45              


Tyr Leu Tyr Thr Asp Asp Asp Gln Asp Thr Glu Ala His Leu Glu Ile 
    50                  55                  60                  


Arg Glu Asp Gly Thr Val Val Gly Ala Ala His Arg Ser Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
                85                  90                  95      


Val Lys Ala Ser Arg Phe Leu Cys Gln Gln Pro Asp Gly Ala Leu Tyr 
            100                 105                 110         


Gly Ser Pro His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
        115                 120                 125             


Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
    130                 135                 140                 


Leu Arg Leu Pro Gln Lys Asp Ser Pro Asn Gln Asp Ala Thr Ser Trp 
145                 150                 155                 160 


Gly Pro Val Arg Phe Leu Pro Met Pro Gly Leu Leu His Glu Pro Gln 
                165                 170                 175     


Asp Gln Ala Gly Phe Leu Pro Pro Glu Pro Pro Asp Val Gly Ser Ser 
            180                 185                 190         


Asp Pro Leu Ser Met Val Glu Pro Leu Gln Gly Arg Ser Pro Ser Tyr 
        195                 200                 205             


Ala Ser 
    210 


<210> 6
<211> 208
<212> PRT
<213> Homo sapiens

<400> 6
Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro Asp 
            20                  25                  30          


Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 
        35                  40                  45              


Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu 
    50                  55                  60                  


Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 
65                  70                  75                  80  


Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 
                85                  90                  95      


Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 
            100                 105                 110         


Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 
    130                 135                 140                 


Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro 
145                 150                 155                 160 


Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro 
                165                 170                 175     


Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 
            180                 185                 190         


Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        195                 200                 205             


<210> 7
<211> 3247
<212> DNA
<213> Homo sapiens

<400> 7
accctgggcc tggcccaaga aactatacat tcctcctggg aatctggggc tgtgatggga       60

ggggttgcca tgaagacttc tgacatgccc tggagacatt ttccccatgg tcttggggat      120

taacattcag ctccttgtta cttatgcaaa tttctgcagc tggcttgaat ttctcctcag      180

aaaatgagat tttcttttct atcgcattgt caggctgcaa attttccaaa cttttgtgct      240

ctgcttccct tataaaactg aaggcctggc caggtgtggt ggctcacgcc tgtaatccca      300

gcactttggg gagctgagac gggcgaatca cgaggtcagg agttcgagac cagcctggcc      360

aacatggtga aaccctgtct ctactaaaaa tacaaaaagt tagctgggca tagtcatggg      420

tgcctttaat cccagctact tgggagactg aggcaggaga atcgtttgaa tccaggaggc      480

ggaggttgca gtgagtcgag atcacaccac tgcactccag ccctggtaac atagtaagac      540

tctgtctcaa aaaaaaaaaa aaaaaaacaa aactgaatgc ctttaacaac acccaagttg      600

cttcttgaat gctttgctgc ttagaaattt cttctgccag ataccctaaa tcatctctct      660

taggttccaa gttccacaaa tctctagggc agggacaaaa cgctgccagt ctctttacta      720

aaacataaca agagtcaccc ttgctctagt tcccaaaaag ttcctcatct ccatctgaaa      780

ccacccccgc ctagatttcg ttgtccatat cattatcagc attttggtca aagtcattca      840

acaggcctct agggagttcc aaacttgctc acattctcct gtcttcttct gagccctcca      900

aactgttcca atccctacct gttacccagt tccaaagtcg cttccacatt tttggttatc      960

ttttcagccg tgccccactc tactggtacc agtttactgt attagtcgat tttcatgctg     1020

ctgataaaga catacctgaa actggacaat ttacaaaaga aagaggttta ttggacttac     1080

aattctacat cacttgggag gcctcacaat catgatggaa ggagaaaggc acatctcaca     1140

tggcagcaga caagaaaaga gcttgtgcag ggaaactcct ctttttaaaa ccatcagatc     1200

tcatgaaatt tattcattat catgacaata gcacaggaaa gaactgcacc cataattcag     1260

tcacctccta ccaggttcct cccacaacac gtgagaattc aagatgagat ttggatgggg     1320

acacagccaa accatgtcac actaccatgc ctgacttcct ttccattttt gtatatttgc     1380

ttgttcttca tttgcccgag aagtaactct aaagggctgt attatttgga tattagattg     1440

gcattttatc tgactgggat atcttgctgt gattgtccat gtataagatc agcttttcta     1500

taaaccatat ttttaaaaag atatattaat tttttaaaaa tccacctgtc taaataaatg     1560

cacaaagccc cccaaaaacc tagattctaa gaaaaatcta tgtactgcca tacaatgatt     1620

gatattaata tttatggtga taaattacac acaaaaaatg tgtgatctct gtttaaacag     1680

gcaaaaacaa aaaacacatg aaataaatct atggcatcta tagccaaaac tggaaacaac     1740

ccacatatcc atcaatagga aatcagttaa ataaattata gtacatttat ccaatggaag     1800

attaagcaca tattcaatat aattatttat acacacatat agatacacac atgtataaat     1860

atagagaata ctgtgggtgt atgtgtgtgt gtgtttatat acatatatat acacacacag     1920

tactgttgcc taccttcttt tgtcttaatt ctgtgaactc tcattcactc tgcttcagta     1980

ggatacatcc ttctttttgg ttcttagact caccaagttg atccttgact caagacattg     2040

catttgctgc ttcctcttcc tggaatatcc ttccttctga tattcacatg agtagtctct     2100

tcttgtcatt cagatctcaa atgtcacaat ttcagagagc ccatctctga tcatcatatc     2160

taaagttgtc ctcattcccc catagctttc tataccatgt tttatttttt tcataacatg     2220

tattttatta ctcctttctc cattggaata gaatctccat tagattagga aatctgccta     2280

tcttattaat gcctgcaact ggaatacttt tgaagagttc ttggcacgta ataaatactc     2340

aactaatatt tttgtgtaca cagaaataaa gtttggaaga acagatgcca aattgttact     2400

agtggttact tctgagtaaa ggagtagcat ggtaggtaaa ttattaatag atgttcactt     2460

tccaccaaga tatgttttag ttagtcttaa cttacttgaa atgaaattta ttactttaat     2520

aattagaaac attgataaac attttagtca caagaatgat agataaaatt ttgatgcttc     2580

caataagtta tatttatcta gaggatgcac ttatgtagaa tactctcttg aggatgttag     2640

gtgagtaaca tgttactata tgtagtaaaa tatctatgat tttataaaag cactgaaaca     2700

tgaagcagca gaaacgtttt tcccagttct ctttcctctg aacttgatca ccgtctctct     2760

ggcaaagcac ctaaattaat tcttctttaa aagttaacaa gaccaaatta taagcttgat     2820

gaataactca ttcttatctt tctttaaatg attatagttt atgtatttat tagctatgcc     2880

catcttaaac aggtttattt gttcttttta cacataccaa actcttaata ttagctgttg     2940

tccccaggtc cgaatgttaa gtcaacatat atttgagaga acttcaactt atcaagtatt     3000

gcaggtctct gattgctttg gaaccacttc tgatacctgt ggacttagtt caaggccagt     3060

tactaccact tttttttttc taatagaatg aacaaatggc taattgtttg ctttgtcaac     3120

caagctcaag ttaatggatc tggatactat gtatataaaa agcctagctt gagtctcttt     3180

tcagtggcat ccttcccttt ctaatcagag attttcttcc tcagagattt tggcctagat     3240

ttgcaaa                                                               3247


<210> 8
<211> 6079
<212> DNA
<213> Homo sapiens

<400> 8
atcctcagtc tcccagttca agctaatcat tgacagagct ttacaatcac aagcttttac       60

tgaagctttg ataagacagt ccagcagttg gtggcaaatg aagccaggct gtgcggcagg      120

atctccaggg aatgaatgga ttttcttcag cactgatgaa ataaccacac gctataggaa      180

tacaatgtcc aacgggggat tgcaaagatc tgtcatcctg tcagcactta ttctgctacg      240

agctgttact ggattctctg gagatggaag agctatatgg tctaaaaatc ctaattttac      300

tccggtaaat gaaagtcagc tgtttctcta tgacactttc cctaaaaact ttttctgggg      360

tattgggact ggagcattgc aagtggaagg gagttggaag aaggatggaa aaggaccttc      420

tatatgggat catttcatcc acacacacct taaaaatgtc agcagcacga atggttccag      480

tgacagttat atttttctgg aaaaagactt atcagccctg gattttatag gagtttcttt      540

ttatcaattt tcaatttcct ggccaaggct tttccccgat ggaatagtaa cagttgccaa      600

cgcaaaaggt ctgcagtact acagtactct tctggacgct ctagtgctta gaaacattga      660

acctatagtt actttatacc actgggattt gcctttggca ctacaagaaa aatatggggg      720

gtggaaaaat gataccataa tagatatctt caatgactat gccacatact gtttccagat      780

gtttggggac cgtgtcaaat attggattac aattcacaac ccatatctag tggcttggca      840

tgggtatggg acaggtatgc atgcccctgg agagaaggga aatttagcag ctgtctacac      900

tgtgggacac aacttgatca aggctcactc gaaagtttgg cataactaca acacacattt      960

ccgcccacat cagaagggtt ggttatcgat cacgttggga tctcattgga tcgagccaaa     1020

ccggtcggaa aacacgatgg atatattcaa atgtcaacaa tccatggttt ctgtgcttgg     1080

atggtttgcc aaccctatcc atggggatgg cgactatcca gaggggatga gaaagaagtt     1140

gttctccgtt ctacccattt tctctgaagc agagaagcat gagatgagag gcacagctga     1200

tttctttgcc ttttcttttg gacccaacaa cttcaagccc ctaaacacca tggctaaaat     1260

gggacaaaat gtttcactta atttaagaga agcgctgaac tggattaaac tggaatacaa     1320

caaccctcga atcttgattg ctgagaatgg ctggttcaca gacagtcgtg tgaaaacaga     1380

agacaccacg gccatctaca tgatgaagaa tttcctcagc caggtgcttc aagcaataag     1440

gttagatgaa atacgagtgt ttggttatac tgcctggtct ctcctggatg gctttgaatg     1500

gcaggatgct tacaccatcc gccgaggatt attttatgtg gattttaaca gtaaacagaa     1560

agagcggaaa cctaagtctt cagcacacta ctacaaacag atcatacgag aaaatggttt     1620

ttctttaaaa gagtccacgc cagatgtgca gggccagttt ccctgtgact tctcctgggg     1680

tgtcactgaa tctgttctta agcccgagtc tgtggcttcg tccccacagt tcagcgatcc     1740

tcatctgtac gtgtggaacg ccactggcaa cagactgttg caccgagtgg aaggggtgag     1800

gctgaaaaca cgacccgctc aatgcacaga ttttgtaaac atcaaaaaac aacttgagat     1860

gttggcaaga atgaaagtca cccactaccg gtttgctctg gattgggcct cggtccttcc     1920

cactggcaac ctgtccgcgg tgaaccgaca ggccctgagg tactacaggt gcgtggtcag     1980

tgaggggctg aagcttggca tctccgcgat ggtcaccctg tattatccga cccacgccca     2040

cctaggcctc cccgagcctc tgttgcatgc cgacgggtgg ctgaacccat cgacggccga     2100

ggccttccag gcctacgctg ggctgtgctt ccaggagctg ggggacctgg tgaagctctg     2160

gatcaccatc aacgagccta accggctaag tgacatctac aaccgctctg gcaacgacac     2220

ctacggggcg gcgcacaacc tgctggtggc ccacgccctg gcctggcgcc tctacgaccg     2280

gcagttcagg ccctcacagc gcggggccgt gtcgctgtcg ctgcacgcgg actgggcgga     2340

acccgccaac ccctatgctg actcgcactg gagggcggcc gagcgcttcc tgcagttcga     2400

gatcgcctgg ttcgccgagc cgctcttcaa gaccggggac taccccgcgg ccatgaggga     2460

atacattgcc tccaagcacc gacgggggct ttccagctcg gccctgccgc gcctcaccga     2520

ggccgaaagg aggctgctca agggcacggt cgacttctgc gcgctcaacc acttcaccac     2580

taggttcgtg atgcacgagc agctggccgg cagccgctac gactcggaca gggacatcca     2640

gtttctgcag gacatcaccc gcctgagctc ccccacgcgc ctggctgtga ttccctgggg     2700

ggtgcgcaag ctgctgcggt gggtccggag gaactacggc gacatggaca tttacatcac     2760

cgccagtggc atcgacgacc aggctctgga ggatgaccgg ctccggaagt actacctagg     2820

gaagtacctt caggaggtgc tgaaagcata cctgattgat aaagtcagaa tcaaaggcta     2880

ttatgcattc aaactggctg aagagaaatc taaacccaga tttggattct tcacatctga     2940

ttttaaagct aaatcctcaa tacaatttta caacaaagtg atcagcagca ggggcttccc     3000

ttttgagaac agtagttcta gatgcagtca gacccaagaa aatacagagt gcactgtctg     3060

cttattcctt gtgcagaaga aaccactgat attcctgggt tgttgcttct tctccaccct     3120

ggttctactc ttatcaattg ccatttttca aaggcagaag agaagaaagt tttggaaagc     3180

aaaaaactta caacacatac cattaaagaa aggcaagaga gttgttagct aaactgatct     3240

gtctgcatga tagacagttt aaaaattcat cccagttcca tatgctggta acttacagga     3300

gatatacctg tattatagaa agacaatctg agatacagct gtaaccaagg tgatgacaat     3360

tgtctctgct gtgtggttca aagaacattc ccttaggtgt tgacatcagt gaactcagtt     3420

cttggatgta aacataaagg cttcatcctg acagtaagct atgaggatta catgctacat     3480

tgcttcttaa agtttcatca actgtattcc atcattctgc tttagctttc atctctacca     3540

atagctactt gtggtacaat aaattatttt taagaagtaa aactctgggg ctggacgctg     3600

tggctcacac ctgtaatctc agcactttgg gaggccgagg cggggagatc acctgaggtg     3660

aggagttcga gaccagcctg gccaacatgg tgaaaccatg tctctactaa aaatacaaaa     3720

aattagccag gcgtggtgac agtggcacct gtaatcccag ctacttggga ggctgaggca     3780

gaagtttgaa cccaggaaac aggttacagt aggccaaaat tgcgccactg cactccagcc     3840

taggcgacaa cagcaagact gtgtccaaaa aaaaaaaaaa aagcaaaagc aaaactttgt     3900

tttgttagac tctacagcag agatttaaca cccttcttta aactgggtag tcagtgatag     3960

ataatatata ttctgtcact tctaataagg tgccttctcc tttaggtcag ggtggttcta     4020

aaatggaaag aaaacacaat agggtaagta gtgcttgtct aagccagtta caacacagac     4080

tcttaaagag gatcaagccc ttcatttttc taacaacaaa aaatcaccta tagaatatct     4140

aatttgtgat cttttactag atctgatttt ttaaaataat gtaatttccg gccaggcacg     4200

gtggcaccgc ctgtaatccc agcactttgg gaggccaagg caggtggatc acctgaggtt     4260

aggagttcga gactagcctg gccaacatgg caaaacccca tctctactaa aaatacaaaa     4320

gttagccggg catggtggtg ggcacctgta atcccagcta ctcaggaggc cgaggcagga     4380

gaatcgcttg aacccgagag gcagaggttg caatgagcca agatcgtgcc attgcactcc     4440

agcctggggg acagggcaag actgtctctc aaaataaaaa aaaataataa aaataaaaat     4500

aaaagtaatt tccaaaacct catctcatgg aaagatcaca ggatgaagga aagctagact     4560

caactctgtg aatagaagtt gctatactgt aagtaaagca acaattcaga atactgaatg     4620

agtttaaatt gttttatata gcaccctttt gggctagggt taattactag atctgacttg     4680

gataatttga cactttggga aatgaactct gttcttgaga cttgttcagt gtattttaaa     4740

catctgagga agaaaactta aatatgcacc tatttatacc tattctttct ttaggtcaac     4800

atttaacacc cactgcatac attaatttgt ccttgtctgc tcactccagc aatttagacc     4860

ttaacagtca caagagacgt tcttctgtta caaagcctta gtaaattaag gcagttttga     4920

ttatattcta ggtccaccta tgtctgaagc taaattcagt atctaactgc taatgaacaa     4980

gtttccaaaa tactgtaaaa atacaattag tcaatttgag taaatgcaaa tatgatgaga     5040

aatcaatttg ctatttggcc tggcaaatgg gaacagtaaa attctgcttt actcttctct     5100

agtctccttg ccccagctgc acccactacc ccaaagttgg cagttttgag gtatgatttt     5160

caaggaattt ttttagtatt aacatctccc tctgagaact atgtacctaa ggtcacgcat     5220

acaactagtc aattctgttt ttattactct aactatgtag aaacagtaag tcacttaaaa     5280

caatcacttg gctgggtttt ttcccctttg tgccacattg attcaccctg acccaagaac     5340

tccagggaaa attctttaat gtcaactggg caactcatta acctctcttt aacatcaagg     5400

gcttgggaaa aaaaaaaaaa aggttagcca caggaataac aaaaacctgg aatttatctt     5460

tcaggttttg ctttctcttt ctcactttgt ttaaagtatc tcgtactcac agttcacaaa     5520

ttaaccttca ctgtctcttt cacattaaga gcttatgctt aaagcatgcc ccccttttct     5580

aacttgctgg tttaccataa actcccctaa gtaataaaat tcctaaccca gtactgagag     5640

tcctccttct ctgccacttg ggcattattt tactagtttt taagccatca tcgcacaaga     5700

atccaaaaac ccttaaattt tttaaccact ggcaaatatg tacagcaaat taggttaagc     5760

atttaatctg gctcatgctc tatcatacta aatattcagg tttatcataa actccttaaa     5820

aaccatcaaa ggtcaaccag aaactgataa ctcttgaaag gagcaaacag gtaagatctt     5880

tggagtttaa gcttttctga gatgtgttgt gaaaaatcta acgtgtttat cgtatattca     5940

atgtaacaac ctggagaatc acaactatat ttaaagagcc tctggaaaat gaggccagta     6000

cagtgtgact acatgtttaa ttttcaatgt aatttattcc aaataaactg gttcatgctg     6060

accacttgta ttcaactaa                                                  6079


<210> 9
<211> 1044
<212> PRT
<213> Homo sapiens

<400> 9
Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn 
            20                  25                  30          


Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg 
        35                  40                  45              


Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn 
    50                  55                  60                  


Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr 
65                  70                  75                  80  


Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val 
                85                  90                  95      


Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His 
            100                 105                 110         


Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser 
        115                 120                 125             


Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile 
    130                 135                 140                 


Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro 
145                 150                 155                 160 


Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser 
                165                 170                 175     


Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly 
        195                 200                 205             


Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr 
    210                 215                 220                 


Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His 
225                 230                 235                 240 


Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala 
                245                 250                 255     


Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn 
            260                 265                 270         


Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe 
        275                 280                 285             


Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln 
305                 310                 315                 320 


Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly 
                325                 330                 335     


Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu 
            340                 345                 350         


Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp 
        355                 360                 365             


Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr 
    370                 375                 380                 


Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu 
385                 390                 395                 400 


Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu 
                405                 410                 415     


Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala 
            420                 425                 430         


Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg 
        435                 440                 445             


Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp 
    450                 455                 460                 


Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala 
                485                 490                 495     


His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu 
            500                 505                 510         


Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly 
        515                 520                 525             


Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln 
    530                 535                 540                 


Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu 
545                 550                 555                 560 


Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys 
                565                 570                 575     


Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met 
            580                 585                 590         


Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro 
        595                 600                 605             


Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg 
    610                 615                 620                 


Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr 
625                 630                 635                 640 


Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu 
                645                 650                 655     


His Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala 
            660                 665                 670         


Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp 
        675                 680                 685             


Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser 
    690                 695                 700                 


Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala 
705                 710                 715                 720 


Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly 
                725                 730                 735     


Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro 
            740                 745                 750         


Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu 
        755                 760                 765             


Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala 
    770                 775                 780                 


Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser 
785                 790                 795                 800 


Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly 
                805                 810                 815     


Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met 
            820                 825                 830         


His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln 
        835                 840                 845             


Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val 
    850                 855                 860                 


Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr 
865                 870                 875                 880 


Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala 
                885                 890                 895     


Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln 
            900                 905                 910         


Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr 
        915                 920                 925             


Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe 
    930                 935                 940                 


Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys 
945                 950                 955                 960 


Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys 
                965                 970                 975     


Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val 
            980                 985                 990         


Gln Lys Lys Pro Leu Ile Phe Leu  Gly Cys Cys Phe Phe  Ser Thr Leu 
        995                 1000                 1005             


Val Leu  Leu Leu Ser Ile Ala  Ile Phe Gln Arg Gln  Lys Arg Arg 
    1010                 1015                 1020             


Lys Phe  Trp Lys Ala Lys Asn  Leu Gln His Ile Pro  Leu Lys Lys 
    1025                 1030                 1035             


Gly Lys  Arg Val Val Ser 
    1040                 


<210> 10
<211> 3439
<212> DNA
<213> Mus musculus

<400> 10
aatgaagaca ggctgtgcag cagggtctcc ggggaatgaa tggattttct tcagctctga       60

tgaaagaaac acacgctcta ggaaaacaat gtccaacagg gcactgcaaa gatctgccgt      120

gctgtctgcg tttgttctgc tgcgagctgt taccggcttc tccggagacg ggaaagcaat      180

atgggataaa aaacagtacg tgagtccggt aaacccaagt cagctgttcc tctatgacac      240

tttccctaaa aacttttcct ggggcgttgg gaccggagca tttcaagtgg aagggagttg      300

gaagacagat ggaagaggac cctcgatctg ggatcggtac gtctactcac acctgagagg      360

tgtcaacggc acagacagat ccactgacag ttacatcttt ctggaaaaag acttgttggc      420

tctggatttt ttaggagttt ctttttatca gttctcaatc tcctggccac ggttgtttcc      480

caatggaaca gtagcagcag tgaatgcgca aggtctccgg tactaccgtg cacttctgga      540

ctcgctggta cttaggaata tcgagcccat tgttaccttg taccattggg atttgcctct      600

gacgctccag gaagaatatg ggggctggaa aaatgcaact atgatagatc tcttcaacga      660

ctatgccaca tactgcttcc agacctttgg agaccgtgtc aaatattgga ttacaattca      720

caacccttac cttgttgctt ggcatgggtt tggcacaggt atgcatgcac caggagagaa      780

gggaaattta acagctgtct acactgtggg acacaacctg atcaaggcac attcgaaagt      840

gtggcataac tacgacaaaa acttccgccc tcatcagaag ggttggctct ccatcacctt      900

ggggtcccat tggatagagc caaacagaac agacaacatg gaggacgtga tcaactgcca      960

gcactccatg tcctctgtgc ttggatggtt cgccaacccc atccacgggg acggcgacta     1020

ccctgagttc atgaagacgg gcgccatgat ccccgagttc tctgaggcag agaaggagga     1080

ggtgaggggc acggctgatt tctttgcctt ttccttcggg cccaacaact tcaggccctc     1140

aaacaccgtg gtgaaaatgg gacaaaatgt atcactcaac ttaaggcagg tgctgaactg     1200

gattaaactg gaatacgatg accctcaaat cttgatttcg gagaacggct ggttcacaga     1260

tagctatata aagacagagg acaccacggc catctacatg atgaagaatt tcctaaacca     1320

ggttcttcaa gcaataaaat ttgatgaaat ccgcgtgttt ggttatacgg cctggactct     1380

cctggatggc tttgagtggc aggatgccta tacgacccga cgagggctgt tttatgtgga     1440

ctttaacagt gagcagaaag agaggaaacc caagtcctcg gctcattact acaagcagat     1500

catacaagac aacggcttcc ctttgaaaga gtccacgcca gacatgaagg gtcggttccc     1560

ctgtgatttc tcttggggag tcactgagtc tgttcttaag cccgagttta cggtctcctc     1620

cccgcagttt accgatcctc acctgtatgt gtggaatgtc actggcaaca gattgctcta     1680

ccgagtggaa ggggtaaggc tgaaaacaag accatcccag tgcacagatt atgtgagcat     1740

caaaaaacga gttgaaatgt tggcaaaaat gaaagtcacc cactaccagt ttgctctgga     1800

ctggacctct atccttccca ctggcaatct gtccaaagtt aacagacaag tgttaaggta     1860

ctataggtgt gtggtgagcg aaggactgaa gctgggcgtc ttccccatgg tgacgttgta     1920

ccacccaacc cactcccatc tcggcctccc cctgccactt ctgagcagtg gggggtggct     1980

aaacatgaac acagccaagg ccttccagga ctacgctgag ctgtgcttcc gggagttggg     2040

ggacttggtg aagctctgga tcaccatcaa tgagcctaac aggctgagtg acatgtacaa     2100

ccgcacgagt aatgacacct accgtgcagc ccacaacctg atgatcgccc atgcccaggt     2160

ctggcacctc tatgataggc agtataggcc ggtccagcat ggggctgtgt cgctgtcctt     2220

acattgcgac tgggcagaac ctgccaaccc ctttgtggat tcacactgga aggcagccga     2280

gcgcttcctc cagtttgaga tcgcctggtt tgcagatccg ctcttcaaga ctggcgacta     2340

tccatcggtt atgaaggaat acatcgcctc caagaaccag cgagggctgt ctagctcagt     2400

cctgccgcgc ttcaccgcga aggagagcag gctggtgaag ggtaccgtcg acttctacgc     2460

actgaaccac ttcactacga ggttcgtgat acacaagcag ctgaacacca accgctcagt     2520

tgcagacagg gacgtccagt tcctgcagga catcacccgc ctaagctcgc ccagccgcct     2580

ggctgtaaca ccctggggag tgcgcaagct ccttgcgtgg atccggagga actacagaga     2640

cagggatatc tacatcacag ccaatggcat cgatgacctg gctctagagg atgatcagat     2700

ccgaaagtac tacttggaga agtatgtcca ggaggctctg aaagcatatc tcattgacaa     2760

ggtcaaaatc aaaggctact atgcattcaa actgactgaa gagaaatcta agcctagatt     2820

tggatttttc acctctgact tcagagctaa gtcctctgtc cagttttaca gcaagctgat     2880

cagcagcagt ggcctccccg ctgagaacag aagtcctgcg tgtggtcagc ctgcggaaga     2940

cacagactgc accatttgct catttctcgt ggagaagaaa ccactcatct tcttcggttg     3000

ctgcttcatc tccactctgg ctgtactgct atccatcacc gtttttcatc atcaaaagag     3060

aagaaaattc cagaaagcaa ggaacttaca aaatatacca ttgaagaaag gccacagcag     3120

agttttcagc taaactgcca tttctgtcat agtttcaaga ttcactccgg ctccatgtac     3180

tggtaactta cgatgtgaga gacagctgta accaaggtga agacaatcga tgcctctgaa     3240

gtgtggttca aataattcct tcaggtcccg acaatcagtg agtccgttct ccgagctgaa     3300

gacaccctga cagtaactct gggcgtgacc ctaaacatcg cttcaggaag tgtgaatcac     3360

gacttcacat cctttttctc tagcattctt ctgtaaataa caatcactat tcatggtcaa     3420

gaaattaatt ttaaaaagt                                                  3439


<210> 11
<211> 1040
<212> PRT
<213> Mus musculus

<400> 11
Met Lys Thr Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Ser Asp Glu Arg Asn Thr Arg Ser Arg Lys Thr Met Ser Asn 
            20                  25                  30          


Arg Ala Leu Gln Arg Ser Ala Val Leu Ser Ala Phe Val Leu Leu Ala 
        35                  40                  45              


Val Thr Gly Ser Gly Asp Gly Lys Ala Trp Asp Lys Lys Gln Tyr Val 
    50                  55                  60                  


Ser Pro Val Asn Pro Ser Gln Leu Phe Leu Tyr Asp Thr Phe Pro Lys 
65                  70                  75                  80  


Asn Phe Ser Trp Gly Val Gly Thr Gly Ala Phe Gln Val Glu Gly Ser 
                85                  90                  95      


Trp Lys Thr Asp Gly Arg Gly Pro Ser Ile Trp Asp Arg Tyr Val Tyr 
            100                 105                 110         


Ser His Leu Arg Gly Val Asn Gly Thr Asp Arg Ser Thr Asp Ser Tyr 
        115                 120                 125             


Ile Phe Leu Glu Lys Asp Leu Leu Ala Leu Asp Phe Leu Gly Val Ser 
    130                 135                 140                 


Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asn Gly Thr 
145                 150                 155                 160 


Val Ala Ala Val Asn Ala Gln Gly Leu Arg Tyr Tyr Arg Ala Leu Leu 
                165                 170                 175     


Asp Ser Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His 
            180                 185                 190         


Trp Asp Leu Pro Leu Thr Leu Gln Glu Glu Tyr Gly Gly Trp Lys Asn 
        195                 200                 205             


Ala Thr Met Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr Cys Phe Gln 
    210                 215                 220                 


Thr Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn Pro Tyr 
225                 230                 235                 240 


Leu Val Ala Trp His Gly Phe Gly Thr Gly Met His Ala Pro Gly Glu 
                245                 250                 255     


Lys Gly Asn Leu Thr Ala Val Tyr Thr Val Gly His Asn Leu Ile Lys 
            260                 265                 270         


Ala His Ser Lys Val Trp His Asn Tyr Asp Lys Asn Phe Arg Pro His 
        275                 280                 285             


Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile Glu Pro 
    290                 295                 300                 


Asn Arg Thr Asp Asn Met Glu Asp Val Ile Asn Cys Gln His Ser Met 
305                 310                 315                 320 


Ser Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Phe Met Lys Thr Gly Ala Met Ile Pro Glu Phe Ser Glu 
            340                 345                 350         


Ala Glu Lys Glu Glu Val Arg Gly Thr Ala Asp Phe Phe Ala Phe Ser 
        355                 360                 365             


Phe Gly Pro Asn Asn Phe Arg Pro Ser Asn Thr Val Val Lys Met Gly 
    370                 375                 380                 


Gln Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn Trp Ile Lys Leu 
385                 390                 395                 400 


Glu Tyr Asp Asp Pro Gln Ile Leu Ile Ser Glu Asn Gly Trp Phe Thr 
                405                 410                 415     


Asp Ser Tyr Ile Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met Met Lys 
            420                 425                 430         


Asn Phe Leu Asn Gln Val Leu Gln Ala Ile Lys Phe Asp Glu Ile Arg 
        435                 440                 445             


Val Phe Gly Tyr Thr Ala Trp Thr Leu Leu Asp Gly Phe Glu Trp Gln 
    450                 455                 460                 


Asp Ala Tyr Thr Thr Arg Arg Gly Leu Phe Tyr Val Asp Phe Asn Ser 
465                 470                 475                 480 


Glu Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr Tyr Lys Gln 
                485                 490                 495     


Ile Ile Gln Asp Asn Gly Phe Pro Leu Lys Glu Ser Thr Pro Asp Met 
            500                 505                 510         


Lys Gly Arg Phe Pro Cys Asp Phe Ser Trp Gly Val Thr Glu Ser Val 
        515                 520                 525             


Leu Lys Pro Glu Phe Thr Val Ser Ser Pro Gln Phe Thr Asp Pro His 
    530                 535                 540                 


Leu Tyr Val Trp Asn Val Thr Gly Asn Arg Leu Leu Tyr Arg Val Glu 
545                 550                 555                 560 


Gly Val Arg Leu Lys Thr Arg Pro Ser Gln Cys Thr Asp Tyr Val Ser 
                565                 570                 575     


Ile Lys Lys Arg Val Glu Met Leu Ala Lys Met Lys Val Thr His Tyr 
            580                 585                 590         


Gln Phe Ala Leu Asp Trp Thr Ser Ile Leu Pro Thr Gly Asn Leu Ser 
        595                 600                 605             


Lys Val Asn Arg Gln Val Leu Arg Tyr Tyr Arg Cys Val Val Ser Glu 
    610                 615                 620                 


Gly Leu Lys Leu Gly Val Phe Pro Met Val Thr Leu Tyr His Pro Thr 
625                 630                 635                 640 


His Ser His Leu Gly Leu Pro Leu Pro Leu Leu Ser Ser Gly Gly Trp 
                645                 650                 655     


Leu Asn Met Asn Thr Ala Lys Ala Phe Gln Asp Tyr Ala Glu Leu Cys 
            660                 665                 670         


Phe Arg Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr Ile Asn Glu 
        675                 680                 685             


Pro Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr Ser Asn Asp Thr Tyr 
    690                 695                 700                 


Arg Ala Ala His Asn Leu Met Ile Ala His Ala Gln Val Trp His Leu 
705                 710                 715                 720 


Tyr Asp Arg Gln Tyr Arg Pro Val Gln His Gly Ala Val Ser Leu Ser 
                725                 730                 735     


Leu His Cys Asp Trp Ala Glu Pro Ala Asn Pro Phe Val Asp Ser His 
            740                 745                 750         


Trp Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala Trp Phe Ala 
        755                 760                 765             


Asp Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ser Val Met Lys Glu Tyr 
    770                 775                 780                 


Ile Ala Ser Lys Asn Gln Arg Gly Leu Ser Ser Ser Val Leu Pro Arg 
785                 790                 795                 800 


Phe Thr Ala Lys Glu Ser Arg Leu Val Lys Gly Thr Val Asp Phe Tyr 
                805                 810                 815     


Ala Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys Gln Leu Asn 
            820                 825                 830         


Thr Asn Arg Ser Val Ala Asp Arg Asp Val Gln Phe Leu Gln Asp Ile 
        835                 840                 845             


Thr Arg Leu Ser Ser Pro Ser Arg Leu Ala Val Thr Pro Trp Gly Val 
    850                 855                 860                 


Arg Lys Leu Leu Ala Trp Ile Arg Arg Asn Tyr Arg Asp Arg Asp Ile 
865                 870                 875                 880 


Tyr Ile Thr Ala Asn Gly Ile Asp Asp Leu Ala Leu Glu Asp Asp Gln 
                885                 890                 895     


Ile Arg Lys Tyr Tyr Leu Glu Lys Tyr Val Gln Glu Ala Leu Lys Ala 
            900                 905                 910         


Tyr Leu Ile Asp Lys Val Lys Ile Lys Gly Tyr Tyr Ala Phe Lys Leu 
        915                 920                 925             


Thr Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr Ser Asp Phe 
    930                 935                 940                 


Arg Ala Lys Ser Ser Val Gln Phe Tyr Ser Lys Leu Ile Ser Ser Ser 
945                 950                 955                 960 


Gly Leu Pro Ala Glu Asn Arg Ser Pro Ala Cys Gly Gln Pro Ala Glu 
                965                 970                 975     


Asp Thr Asp Cys Thr Ile Cys Ser Phe Leu Val Glu Lys Lys Pro Leu 
            980                 985                 990         


Ile Phe Phe Gly Cys Cys Phe Ile  Ser Thr Leu Ala Val  Leu Leu Ser 
        995                 1000                 1005             


Ile Thr  Val Phe His His Gln  Lys Arg Arg Lys Phe  Gln Lys Ala 
    1010                 1015                 1020             


Arg Asn  Leu Gln Asn Ile Pro  Leu Lys Lys Gly His  Ser Arg Val 
    1025                 1030                 1035             


Phe Ser  
    1040 


<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
actctgcgct ggttgaaaaa t                                                 21


<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
ggtggcatag cgaaccttgt a                                                 21


<210> 14
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
gctataaggt acgaaaccag cac                                               23


<210> 15
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
ggttgatgga cccgtattca ttc                                               23


<210> 16
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
gcctgcgtgc tagtgttct                                                    19


<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
taccatcctt agcccagacc g                                                 21


<210> 18
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
tccatgaccg tcgtacacaa t                                                 21


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
atttgacagt attcccggca g                                                 21


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
tgttctgctg cgagctgtta c                                                 21


<210> 21
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
ccggactcac gtactgtttt t                                                 21


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
gaagccgctt atgtgtatcg c                                                 21


<210> 23
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
gaatgggtac attgggaaca gt                                                22


<210> 24
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
ggagatcctt cgaggagcac tt                                                22


<210> 25
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
gcgatttagc agcagatata agaa                                              24


<210> 26
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
aaggacctgg tacatgaact gg                                                22


<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
ggttctgggt gtcaagtgtc g                                                 21


<210> 28
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
tttggcgttc gaggccatt                                                    19


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
caggtccacg catttcagac                                                   20


<210> 30
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
cagacgccac tgtcgcttt                                                    19


<210> 31
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
tgtctttgga actttgtctg caa                                               23


<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
gagcaagggc tgctactcaa g                                                 21


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
aaccgcaggt tcaagtattc c                                                 21


<210> 34
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
tcatggtctt cggaggattc ac                                                22


<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
tcacctccaa gtgtggcaaa g                                                 21


<210> 36
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
ttcaggcagg cagtatcact c                                                 21


<210> 37
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
gaaggtccac gggaaagaca c                                                 21


<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
aagagccgga aatccacgaa a                                                 21


<210> 39
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
gtctcaaaag ggtcagggta ct                                                22


<210> 40
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
cttactgact ggcatgagga tca                                               23


<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
gcagctctag gagcatgtgg                                                   20


<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
gaagccgctt atgtgtatcg c                                                 21


<210> 43
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
gaatgggtac attgggaaca gt                                                22


<210> 44
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
tagatgacca tgagtcgctt gc                                                22


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
gccaaacttg ctccatgtcc                                                   20


<210> 46
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
ggagagtctg actctccctg agaa                                              24


<210> 47
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
cgatgggttc cgtcttggt                                                    19


<210> 48
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
cggttccgat gccctgaggc tctt                                              24


<210> 49
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
cgtcacactt catgatggaa ttga                                              24


